Reply: Vitamin D and ovarian reserve—making clinical decisions

Vitamin D and Ovarian Cancer

Ovarian cancer causes more deaths than any other cancer of the female reproductive system. The vitamin D receptor (VDR) is weakly to moderately expressed in normal ovarian cell, but is more strongly expressed in ovarian cancer line and tumor tissue. In vitro studies have reported that vitamin D administration inhibits cell growth and induces apoptosis in a dose dependent manner in both animal a...

Vitamin D and Dysfunctional Adipose Tissue in Obesity (Authors' Reply).

Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We evaluated the relation between vitamin D and adipocytokines derived from adipose tissue. We studied 50 obese individuals who were classified into different subgroups according to medi...

Vitamin D, calcidiol and calcitriol regulate vitamin D metabolizing enzymes in cervical and ovarian cancer cells.

BACKGROUND The vitamin D metabolizing enzymes 25-, 1α- and 24-hydroxylase are expressed in malignant cells of the cervix and the ovaries. The aim of this study was to obtain further information about the regulation of the aforementioned enzymes by vitamin D, calcidiol and calcitriol in cervical and ovarian cancer. MATERIALS AND METHODS The human cervical adenocarcinoma cell line HeLa and the ...

Cataract and ovarian carcinoma: is the vitamin D hypothesis alive?

BACKGROUND The major health benefit of exposure to solar UV radiation is the production of vitamin D, which is implicated in protection against several human cancers, including ovarian carcinoma. On the other hand, solar UV radiation is a recognized risk factor for cataract. METHODS This population-based case-control study of 709 women with primary invasive ovarian carcinoma and 1,101 control...

Vitamin D: clinical measurement and use.